This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1skg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:26, 25 October 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1skg.gif|left|200px]]
 
-
{{Structure
+
==Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser==
-
|PDB= 1skg |SIZE=350|CAPTION= <scene name='initialview01'>1skg</scene>, resolution 1.21&Aring;
+
<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
<table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SKG FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [https://pdbe.org/1skg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [https://www.ebi.ac.uk/pdbsum/1skg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1fb2|1FB2]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [http://www.ebi.ac.uk/pdbsum/1skg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sk/1skg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1skg ConSurf].
 +
<div style="clear:both"></div>
-
'''Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser'''
+
==See Also==
-
 
+
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1SKG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA].
+
__TOC__
-
[[Category: Daboia russellii pulchella]]
+
</StructureSection>
-
[[Category: Phospholipase A(2)]]
+
[[Category: Daboia russelii pulchella]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Betzel, C.]]
+
[[Category: Betzel C]]
-
[[Category: Dey, S.]]
+
[[Category: Dey S]]
-
[[Category: Ethayathulla, A S.]]
+
[[Category: Ethayathulla AS]]
-
[[Category: Makker, J.]]
+
[[Category: Makker J]]
-
[[Category: Perbandt, M.]]
+
[[Category: Perbandt M]]
-
[[Category: Sharma, S.]]
+
[[Category: Sharma S]]
-
[[Category: Singh, N.]]
+
[[Category: Singh N]]
-
[[Category: Singh, T P.]]
+
[[Category: Singh TP]]
-
[[Category: crystal structure]]
+
-
[[Category: phospholipase a2]]
+
-
[[Category: rational drug design]]
+
-
[[Category: vafrs complex]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:43:19 2008''
+

Current revision

Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser

PDB ID 1skg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1skg"
Personal tools