Isoaspartyl dipeptidase
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load='1ybq' size=' | + | <StructureSection load='1ybq' size='350' side='right' caption='E. coli isoaspartyl dipeptidase complex with aspartylhistidine and Zn+2 ions (PDB code [[1ybq]])' scene='' pspeed='8'> |
== Function == | == Function == | ||
| Line 6: | Line 6: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='75/751803/Cv/ | + | The <scene name='75/751803/Cv/4'>active site</scene> of aspartyl dipeptidase contains the substrate and a <scene name='75/751803/Cv/5'>binuclear metal center which activates the nucleophilic water molecule</scene><ref>PMID:15882050</ref>. |
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of | + | ==3D structures of isoaspartyl dipeptidase== |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| Line 16: | Line 16: | ||
[[1po9]], [[1pok]], [[1onw]] – EcIadA – ''Escherichia coli'' <br /> | [[1po9]], [[1pok]], [[1onw]] – EcIadA – ''Escherichia coli'' <br /> | ||
[[2aqo]], [[2aqv]] – EcIadA (mutant) <br /> | [[2aqo]], [[2aqv]] – EcIadA (mutant) <br /> | ||
| - | [[1ybq]] – EcIadA (mutant) + | + | [[5lp3]] – EcIadA – Cryo EM <br /> |
| + | [[5xgw]] – CpIadA – ''Colwellia psychrerythraea'' <br /> | ||
| + | [[5xgx]] – CpIadA (mutant) <br /> | ||
| + | [[1ybq]] – EcIadA (mutant) + β-Asp-His <br /> | ||
[[1poj]] – EcIadA + inhibitor<br /> | [[1poj]] – EcIadA + inhibitor<br /> | ||
[[1onx]] – EcIadA + aspartate<br /> | [[1onx]] – EcIadA + aspartate<br /> | ||
| - | + | [[7cdh]] – FiIadA – ''Fervidobacterium islandicum'' <br /> | |
| + | [[7cf6]] – FiIadA + β-Asp-Leu <br /> | ||
| + | [[8dqn]] – IadA – ''Leucothrix mucor'' <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of isoaspartyl dipeptidase
Updated on 12-June-2023
1po9, 1pok, 1onw – EcIadA – Escherichia coli
2aqo, 2aqv – EcIadA (mutant)
5lp3 – EcIadA – Cryo EM
5xgw – CpIadA – Colwellia psychrerythraea
5xgx – CpIadA (mutant)
1ybq – EcIadA (mutant) + β-Asp-His
1poj – EcIadA + inhibitor
1onx – EcIadA + aspartate
7cdh – FiIadA – Fervidobacterium islandicum
7cf6 – FiIadA + β-Asp-Leu
8dqn – IadA – Leucothrix mucor
References
- ↑ Michalska K, Brzezinski K, Jaskolski M. Crystal structure of isoaspartyl aminopeptidase in complex with L-aspartate. J Biol Chem. 2005 Aug 5;280(31):28484-91. Epub 2005 Jun 9. PMID:15946951 doi:10.1074/jbc.M504501200
- ↑ Marti-Arbona R, Fresquet V, Thoden JB, Davis ML, Holden HM, Raushel FM. Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli. Biochemistry. 2005 May 17;44(19):7115-24. PMID:15882050 doi:10.1021/bi050008r
