5kaz

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'''Unreleased structure'''
 
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The entry 5kaz is ON HOLD until Paper Publication
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==Human SH2D1B structure==
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<StructureSection load='5kaz' size='340' side='right'caption='[[5kaz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Taha, M., Nezerwa, E., Nam, H.-J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5kaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KAZ FirstGlance]. <br>
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Description: Human SH2D1B structure
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Nezerwa, E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kaz OCA], [https://pdbe.org/5kaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kaz RCSB], [https://www.ebi.ac.uk/pdbsum/5kaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kaz ProSAT]</span></td></tr>
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[[Category: Taha, M]]
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</table>
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[[Category: Nam, H.-J]]
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== Function ==
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[https://www.uniprot.org/uniprot/SH21B_HUMAN SH21B_HUMAN] Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).[UniProtKB:O35324]<ref>PMID:11689425</ref> <ref>PMID:24687958</ref> <ref>PMID:21219180</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Nam H-J]]
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[[Category: Nezerwa E]]
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[[Category: Taha M]]

Current revision

Human SH2D1B structure

PDB ID 5kaz

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OCA

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