5ky6

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'''Unreleased structure'''
 
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The entry 5ky6 is ON HOLD
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==Human muscle fructose-1,6-bisphosphate aldolase==
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<StructureSection load='5ky6' size='340' side='right'caption='[[5ky6]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ky6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KY6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.941&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ky6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ky6 OCA], [https://pdbe.org/5ky6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ky6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ky6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ky6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ALDOA_HUMAN ALDOA_HUMAN] Defects in ALDOA are the cause of glycogen storage disease type 12 (GSD12) [MIM:[https://omim.org/entry/611881 611881]; also known as red cell aldolase deficiency. A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.<ref>PMID:14766013</ref> <ref>PMID:2825199</ref> <ref>PMID:2229018</ref> <ref>PMID:8598869</ref> <ref>PMID:14615364</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDOA_HUMAN ALDOA_HUMAN] Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
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Authors: Wisniewski, J., Barciszewski, J., Jaskolski, M., Rakus, D.
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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Description: Human muscle fructose-1,6-bisphosphate aldolase
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Rakus, D]]
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__TOC__
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[[Category: Barciszewski, J]]
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</StructureSection>
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[[Category: Wisniewski, J]]
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[[Category: Homo sapiens]]
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[[Category: Jaskolski, M]]
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[[Category: Large Structures]]
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[[Category: Barciszewski J]]
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[[Category: Jaskolski M]]
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[[Category: Rakus D]]
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[[Category: Wisniewski J]]

Current revision

Human muscle fructose-1,6-bisphosphate aldolase

PDB ID 5ky6

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