5l03

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'''Unreleased structure'''
 
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The entry 5l03 is ON HOLD until Paper Publication
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==Crystal structure of 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE Synthase from BURKHOLDERIA PSEUDOMALLEI bound to L-tryptophan hydroxamate==
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<StructureSection load='5l03' size='340' side='right'caption='[[5l03]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5l03]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L03 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.469&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6ZB:N-hydroxy-L-tryptophanamide'>6ZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l03 OCA], [https://pdbe.org/5l03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l03 RCSB], [https://www.ebi.ac.uk/pdbsum/5l03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l03 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A069B2G5_BURPE A0A069B2G5_BURPE] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).[HAMAP-Rule:MF_00107][SAAS:SAAS00731896]
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Authors: Blain, J.M., Ghose, D., Gorman, J.L., Goshu, G.M., Ranieri, G., Zhao, L., Bode, B., Meganathan, R., Walter, R.L., Hagen, T.J., Horn, J.R.
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==See Also==
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*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
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Description: Crystal structure of 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE Synthase from BURKHOLDERIA PSEUDOMALLEI bound to L-tryptophan hydroxamate
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Ranieri, G]]
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[[Category: Burkholderia pseudomallei]]
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[[Category: Gorman, J.L]]
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[[Category: Large Structures]]
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[[Category: Horn, J.R]]
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[[Category: Blain JM]]
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[[Category: Blain, J.M]]
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[[Category: Bode B]]
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[[Category: Goshu, G.M]]
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[[Category: Ghose D]]
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[[Category: Ghose, D]]
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[[Category: Gorman JL]]
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[[Category: Meganathan, R]]
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[[Category: Goshu GM]]
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[[Category: Zhao, L]]
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[[Category: Hagen TJ]]
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[[Category: Walter, R.L]]
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[[Category: Horn JR]]
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[[Category: Bode, B]]
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[[Category: Meganathan R]]
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[[Category: Hagen, T.J]]
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[[Category: Ranieri G]]
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[[Category: Walter RL]]
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[[Category: Zhao L]]

Current revision

Crystal structure of 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE Synthase from BURKHOLDERIA PSEUDOMALLEI bound to L-tryptophan hydroxamate

PDB ID 5l03

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OCA

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