5l78
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)== | |
| - | + | <StructureSection load='5l78' size='340' side='right'caption='[[5l78]], [[Resolution|resolution]] 2.68Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l78]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L78 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l78 OCA], [https://pdbe.org/5l78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l78 RCSB], [https://www.ebi.ac.uk/pdbsum/5l78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l78 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Borkowska | + | [https://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry. The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Pena | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Strain-Damerell | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith C]] |
| - | [[Category: | + | [[Category: Arruda P]] |
| + | [[Category: Borkowska O]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Burgess-Brown N]] | ||
| + | [[Category: Chalk R]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Goubin S]] | ||
| + | [[Category: Kopec J]] | ||
| + | [[Category: Pena IA]] | ||
| + | [[Category: Rembeza E]] | ||
| + | [[Category: Strain-Damerell C]] | ||
| + | [[Category: Velupillai S]] | ||
| + | [[Category: Yue WW]] | ||
Current revision
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Arruda P | Borkowska O | Bountra C | Burgess-Brown N | Chalk R | Edwards A | Goubin S | Kopec J | Pena IA | Rembeza E | Strain-Damerell C | Velupillai S | Yue WW
