1spp
From Proteopedia
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| - | [[Image:1spp.gif|left|200px]] | ||
| - | + | ==THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN== | |
| - | + | <StructureSection load='1spp' size='340' side='right'caption='[[1spp]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1spp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SPP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1spp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spp OCA], [https://pdbe.org/1spp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1spp RCSB], [https://www.ebi.ac.uk/pdbsum/1spp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1spp ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/PSP1_PIG PSP1_PIG] Not yet identified, major porcine seminal plasma protein. Can bind soybean trypsin inhibitor after deglycosylation. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spp_consurf.spt"</scriptWhenChecked> | |
| - | == | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1spp ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins involved in sperm-egg binding and display a single CUB domain architecture. We report the crystal structures of porcine seminal plasma PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine aSFP at 2.4 A and 1.9 A resolution respectively. | Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins involved in sperm-egg binding and display a single CUB domain architecture. We report the crystal structures of porcine seminal plasma PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine aSFP at 2.4 A and 1.9 A resolution respectively. | ||
| - | + | The crystal structures of two spermadhesins reveal the CUB domain fold.,Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:9334740<ref>PMID:9334740</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1spp" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Calvete | + | [[Category: Calvete JJ]] |
| - | [[Category: Carvalho | + | [[Category: Carvalho AL]] |
| - | [[Category: Dias | + | [[Category: Dias JM]] |
| - | [[Category: Kolln | + | [[Category: Kolln I]] |
| - | [[Category: Romao | + | [[Category: Romao MJ]] |
| - | [[Category: Romero | + | [[Category: Romero A]] |
| - | [[Category: Sanz | + | [[Category: Sanz L]] |
| - | [[Category: Topfer-Petersen | + | [[Category: Topfer-Petersen E]] |
| - | [[Category: Varela | + | [[Category: Varela PF]] |
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Current revision
THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN
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Categories: Large Structures | Sus scrofa | Calvete JJ | Carvalho AL | Dias JM | Kolln I | Romao MJ | Romero A | Sanz L | Topfer-Petersen E | Varela PF
