5n4g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==human Fab fragment 12E1 against NHBA from Neisseria meningitidis== | |
| + | <StructureSection load='5n4g' size='340' side='right'caption='[[5n4g]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5n4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N4G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n4g OCA], [https://pdbe.org/5n4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n4g RCSB], [https://www.ebi.ac.uk/pdbsum/5n4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n4g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Neisserial heparin-binding antigen (NHBA) is a surface-exposed lipoprotein from Neisseria meningitidis and is a component of the meningococcus B vaccine Bexsero. As part of a study to characterize the three-dimensional structure of NHBA and the molecular basis of the human immune response to Bexsero, the crystal structures of two fragment antigen-binding domains (Fabs) isolated from human monoclonal antibodies targeting NHBA were determined. Through a high-resolution analysis of the organization and the amino-acid composition of the CDRs, these structures provide broad insights into the NHBA epitopes recognized by the human immune system. As expected, these Fabs also show remarkable structural conservation, as shown by a structural comparison of 15 structures of apo Fab 10C3 which were obtained from crystals grown in different crystallization conditions and were solved while searching for a complex with a bound NHBA fragment or epitope peptide. This study also provides indirect evidence for the intrinsically disordered nature of two N-terminal regions of NHBA. | ||
| - | + | Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA.,Maritan M, Cozzi R, Lo Surdo P, Veggi D, Bottomley MJ, Malito E Acta Crystallogr F Struct Biol Commun. 2017 Jun 1;73(Pt 6):305-314. doi:, 10.1107/S2053230X17006021. Epub 2017 May 11. PMID:28580917<ref>PMID:28580917</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5n4g" style="background-color:#fffaf0;"></div> |
| - | [[Category: Malito | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Malito E]] | ||
| + | [[Category: Maritan M]] | ||
Current revision
human Fab fragment 12E1 against NHBA from Neisseria meningitidis
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