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5n8n

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'''Unreleased structure'''
 
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The entry 5n8n is ON HOLD
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==Contracted sheath of a Pseudomonas aeruginosa type six secretion system consisting of TssB1 and TssC1==
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<SX load='5n8n' size='340' side='right' viewer='molstar' caption='[[5n8n]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5n8n]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N8N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.28&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8n OCA], [https://pdbe.org/5n8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n8n RCSB], [https://www.ebi.ac.uk/pdbsum/5n8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSSB1_PSEAE TSSB1_PSEAE] Core component of the H1 type VI (H1-T6SS) secretion system that plays a role in the release of toxins targeting both eukaryotic and prokaryotic species. Forms the sheath of the structure by assembling into tubules together with TssC1 resulting in the stacking of cogwheel-like structures showing predominantly a 12-fold symmetry (PubMed:23341461, PubMed:25305017, PubMed:22906320). The sheath contracts to provide the energy needed for effector delivery (PubMed:29307484).<ref>PMID:22906320</ref> <ref>PMID:23341461</ref> <ref>PMID:25305017</ref> <ref>PMID:29307484</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pseudomonas aeruginosa has three type VI secretion systems (T6SSs), H1-, H2-, and H3-T6SS, each belonging to a distinct group. The two T6SS components, TssB/VipA and TssC/VipB, assemble to form tubules that conserve structural/functional homology with tail sheaths of contractile bacteriophages and pyocins. Here, we used cryoelectron microscopy to solve the structure of the H1-T6SS P. aeruginosa TssB1C1 sheath at 3.3 A resolution. Our structure allowed us to resolve some features of the T6SS sheath that were not resolved in the Vibrio cholerae VipAB and Francisella tularensis IglAB structures. Comparison with sheath structures from other contractile machines, including T4 phage and R-type pyocins, provides a better understanding of how these systems have conserved similar functions/mechanisms despite evolution. We used the P. aeruginosa R2 pyocin as a structural template to build an atomic model of the TssB1C1 sheath in its extended conformation, allowing us to propose a coiled-spring-like mechanism for T6SS sheath contraction.
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Authors:
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Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.,Salih O, He S, Planamente S, Stach L, MacDonald JT, Manoli E, Scheres SHW, Filloux A, Freemont PS Structure. 2017 Dec 21. pii: S0969-2126(17)30404-5. doi:, 10.1016/j.str.2017.12.005. PMID:29307484<ref>PMID:29307484</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5n8n" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Filloux A]]
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[[Category: Freemont PS]]
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[[Category: He S]]
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[[Category: Macdonald JT]]
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[[Category: Manoli E]]
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[[Category: Planamente S]]
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[[Category: Salih O]]
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[[Category: Scheres S]]
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[[Category: Stach L]]

Current revision

Contracted sheath of a Pseudomonas aeruginosa type six secretion system consisting of TssB1 and TssC1

5n8n, resolution 3.28Å

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