1sus

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[[Image:1sus.gif|left|200px]]
 
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{{Structure
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==Crystal structure of alfalfa feruoyl coenzyme A 3-O-methyltransferase==
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|PDB= 1sus |SIZE=350|CAPTION= <scene name='initialview01'>1sus</scene>, resolution 2.70&Aring;
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<StructureSection load='1sus' size='340' side='right'caption='[[1sus]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SPF:SINAPOYL+COENZYME+A'>SPF</scene>
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<table><tr><td colspan='2'>[[1sus]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SUS FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Caffeoyl-CoA_O-methyltransferase Caffeoyl-CoA O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.104 2.1.1.104] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE= CCOMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3879 Medicago sativa])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SPF:SINAPOYL+COENZYME+A'>SPF</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sus OCA], [https://pdbe.org/1sus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sus RCSB], [https://www.ebi.ac.uk/pdbsum/1sus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sus ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1sui|1SUI]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sus OCA], [http://www.ebi.ac.uk/pdbsum/1sus PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sus RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CAMT_MEDSA CAMT_MEDSA] Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
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== Evolutionary Conservation ==
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'''Crystal structure of alfalfa feruoyl coenzyme A 3-O-methyltransferase'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1sus_consurf.spt"</scriptWhenChecked>
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Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in complex with the reaction products S-adenosine-l-homocysteine and feruloyl/sinapoyl CoAs presented here belong to a structurally and mechanistically distinct family of plant small molecule OMTs. These structures provide a new understanding of the substrate preferences and the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of CoA-linked phenylpropanoid substrates.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1SUS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sus ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734921 15734921]
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</StructureSection>
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[[Category: Caffeoyl-CoA O-methyltransferase]]
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[[Category: Large Structures]]
[[Category: Medicago sativa]]
[[Category: Medicago sativa]]
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[[Category: Single protein]]
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[[Category: Dixon RA]]
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[[Category: Dixon, R A.]]
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[[Category: Ferrer J-L]]
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[[Category: Ferrer, J L.]]
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[[Category: Noel JP]]
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[[Category: Noel, J P.]]
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[[Category: Zubieta C]]
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[[Category: Zubieta, C.]]
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[[Category: o-methyltransferase]]
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[[Category: protein-cofactor-substrate complex]]
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[[Category: rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:13 2008''
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Current revision

Crystal structure of alfalfa feruoyl coenzyme A 3-O-methyltransferase

PDB ID 1sus

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