1svz

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[[Image:1svz.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease==
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|PDB= 1svz |SIZE=350|CAPTION= <scene name='initialview01'>1svz</scene>, resolution 1.89&Aring;
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<StructureSection load='1svz' size='340' side='right'caption='[[1svz]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1svz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SVZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1svz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svz OCA], [https://pdbe.org/1svz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1svz RCSB], [https://www.ebi.ac.uk/pdbsum/1svz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1svz ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1jp5|1JP5]], [[1cl2|1Cl2]], [[1n4x|1N4X]], [[1mf2|1MF2]], [[2hrp|2HRP]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1svz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svz OCA], [http://www.ebi.ac.uk/pdbsum/1svz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1svz RCSB]</span>
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[https://www.uniprot.org/uniprot/KV2A7_MOUSE KV2A7_MOUSE]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1svz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1svz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
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'''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease'''
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Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide.,Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587<ref>PMID:15721587</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1svz" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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==About this Structure==
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== References ==
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1SVZ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVZ OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721587 15721587]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Bentley GA]]
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[[Category: Bentley, G A.]]
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[[Category: Brynda J]]
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[[Category: Brynda, J.]]
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[[Category: Fabry M]]
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[[Category: Fabry, M.]]
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[[Category: Horejsi M]]
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[[Category: Horejsi, M.]]
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[[Category: Lescar J]]
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[[Category: Lescar, J.]]
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[[Category: Rezacova P]]
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[[Category: Rezacova, P.]]
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[[Category: Sedlacek J]]
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[[Category: Sedlacek, J.]]
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[[Category: antibody-antigen complex]]
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[[Category: hiv inhibiting antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:41 2008''
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Current revision

Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease

PDB ID 1svz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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