5pye

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'''Unreleased structure'''
 
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The entry 5pye is ON HOLD
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==PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 74)==
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<StructureSection load='5pye' size='340' side='right'caption='[[5pye]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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Authors: Krojer, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5pye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PYE FirstGlance]. <br>
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Description: PanDDA analysis group deposition --Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 74)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Krojer, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pye OCA], [https://pdbe.org/5pye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pye RCSB], [https://www.ebi.ac.uk/pdbsum/5pye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pye ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Bradley AR]]
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[[Category: Brandao-Neto J]]
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[[Category: Brennan PE]]
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[[Category: Collins P]]
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[[Category: Cox O]]
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[[Category: Dias A]]
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[[Category: Douangamath A]]
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[[Category: Edwards A]]
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[[Category: Fairhead M]]
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[[Category: Krojer T]]
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[[Category: MacLean E]]
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[[Category: Ng J]]
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[[Category: Pearce NM]]
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[[Category: Renjie Z]]
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[[Category: Sethi R]]
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[[Category: Talon R]]
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[[Category: Wright N]]
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[[Category: Von Delft F]]

Current revision

PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 74)

PDB ID 5pye

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OCA

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