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5szw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of the RRM1 domain of the post-transcriptional regulator HuR== | |
| - | + | <StructureSection load='5szw' size='340' side='right'caption='[[5szw]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5szw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SZW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5szw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szw OCA], [https://pdbe.org/5szw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5szw RCSB], [https://www.ebi.ac.uk/pdbsum/5szw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5szw ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Jendiroba | + | [https://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Almeida FCL]] | ||
| + | [[Category: Jendiroba KA]] | ||
| + | [[Category: Lima LMTR]] | ||
| + | [[Category: Lixa C]] | ||
| + | [[Category: Mujo A]] | ||
| + | [[Category: Pinheiro AS]] | ||
Current revision
NMR solution structure of the RRM1 domain of the post-transcriptional regulator HuR
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