5t3p

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'''Unreleased structure'''
 
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The entry 5t3p is ON HOLD until Paper Publication
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==Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7==
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<StructureSection load='5t3p' size='340' side='right'caption='[[5t3p]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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Authors: Srikannathasan, V., Nunez, C.A., Tallant, C., Siejka, P., Mathea, S., Kopec, J., Elkins, J.M., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Huber, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5t3p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T3P FirstGlance]. <br>
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Description: Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Huber, K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3p OCA], [https://pdbe.org/5t3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t3p RCSB], [https://www.ebi.ac.uk/pdbsum/5t3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3p ProSAT]</span></td></tr>
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[[Category: Elkins, J.M]]
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</table>
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[[Category: Mathea, S]]
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== Function ==
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[[Category: Arrowsmith, C.H]]
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[https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).
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[[Category: Burgess-Brown, N]]
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__TOC__
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[[Category: Kopec, J]]
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</StructureSection>
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[[Category: Von Delft, F]]
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[[Category: Homo sapiens]]
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[[Category: Nunez, C.A]]
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[[Category: Large Structures]]
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[[Category: Siejka, P]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A.M]]
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[[Category: Bountra C]]
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[[Category: Tallant, C]]
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[[Category: Burgess-Brown N]]
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[[Category: Srikannathasan, V]]
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[[Category: Edwards AM]]
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[[Category: Bountra, C]]
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[[Category: Elkins JM]]
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[[Category: Huber K]]
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[[Category: Kopec J]]
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[[Category: Mathea S]]
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[[Category: Nunez CA]]
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[[Category: Siejka P]]
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[[Category: Srikannathasan V]]
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[[Category: Tallant C]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7

PDB ID 5t3p

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OCA

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