5tet
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==TEV Cleaved Human ATP Citrate Lyase Bound to 4S Hydroxycitrate== | |
| + | <StructureSection load='5tet' size='340' side='right'caption='[[5tet]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5tet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TET FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7A3:3-C-carboxy-2-deoxy-D-erythro-pentaric+acid'>7A3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tet OCA], [https://pdbe.org/5tet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tet RCSB], [https://www.ebi.ac.uk/pdbsum/5tet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tet ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fraser ME]] | ||
| + | [[Category: Hu J]] | ||
Current revision
TEV Cleaved Human ATP Citrate Lyase Bound to 4S Hydroxycitrate
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