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1szt

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[[Image:1szt.gif|left|200px]]
 
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{{Structure
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==ATOMIC STRUCTURE OF A THERMOSTABLE SUBDOMAIN OF HIV-1 GP41==
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|PDB= 1szt |SIZE=350|CAPTION= <scene name='initialview01'>1szt</scene>, resolution 2.4&Aring;
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<StructureSection load='1szt' size='340' side='right'caption='[[1szt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1szt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZT FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE= GP41 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szt OCA], [https://pdbe.org/1szt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szt RCSB], [https://www.ebi.ac.uk/pdbsum/1szt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szt ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szt OCA], [http://www.ebi.ac.uk/pdbsum/1szt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1szt RCSB]</span>
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[https://www.uniprot.org/uniprot/Q3I1N2_9HIV1 Q3I1N2_9HIV1]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sz/1szt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1szt ConSurf].
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<div style="clear:both"></div>
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'''ATOMIC STRUCTURE OF A THERMOSTABLE SUBDOMAIN OF HIV-1 GP41'''
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==See Also==
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*[[Gp41 3D Structures|Gp41 3D Structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41. gp120 directs virion attachment to the cell-surface receptors, and gp41 then promotes viral-cell membrane fusion. A soluble, alpha-helical, trimeric complex within gp41 composed of N-terminal and C-terminal extraviral segments has been proposed to represent the core of the fusion-active conformation of the HIV-1 envelope. A thermostable subdomain denoted N34(L6)C28 can be formed by the N-34 and C-28 peptides connected by a flexible linker in place of the disulfide-bonded loop region. Three-dimensional structure of N34(L6)C28 reveals that three molecules fold into a six-stranded helical bundle. Three N-terminal helices within the bundle form a central, parallel, trimeric coiled coil, whereas three C-terminal helices pack in the reverse direction into three hydrophobic grooves on the surface of the N-terminal trimer. This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV-1 entry.
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==About this Structure==
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1SZT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZT OCA].
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==Reference==
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Atomic structure of a thermostable subdomain of HIV-1 gp41., Tan K, Liu J, Wang J, Shen S, Lu M, Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9356444 9356444]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Lu, M.]]
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[[Category: Lu M]]
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[[Category: Tan, K.]]
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[[Category: Tan K]]
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[[Category: Wang, J H.]]
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[[Category: Wang J-H]]
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[[Category: coat protein]]
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[[Category: hiv-1 envelope glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:49:14 2008''
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Current revision

ATOMIC STRUCTURE OF A THERMOSTABLE SUBDOMAIN OF HIV-1 GP41

PDB ID 1szt

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