1t1n

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[[Image:1t1n.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN==
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|PDB= 1t1n |SIZE=350|CAPTION= <scene name='initialview01'>1t1n</scene>, resolution 2.2&Aring;
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<StructureSection load='1t1n' size='340' side='right'caption='[[1t1n]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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<table><tr><td colspan='2'>[[1t1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trematomus_newnesi Trematomus newnesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1N FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1n OCA], [https://pdbe.org/1t1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1n RCSB], [https://www.ebi.ac.uk/pdbsum/1t1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1n ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1n OCA], [http://www.ebi.ac.uk/pdbsum/1t1n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t1n RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/HBA1_TRENE HBA1_TRENE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha--&gt;Ile, Ala97 (G3)alpha--&gt;Ser and His41 (C7)beta--&gt;Tyr at the alpha1beta2-interface is discussed.
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'''CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN'''
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Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question.,Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:10222199<ref>PMID:10222199</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1t1n" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha--&gt;Ile, Ala97 (G3)alpha--&gt;Ser and His41 (C7)beta--&gt;Tyr at the alpha1beta2-interface is discussed.
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1T1N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Trematomus_newnesi Trematomus newnesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1N OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question., Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A, J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10222199 10222199]
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[[Category: Protein complex]]
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[[Category: Trematomus newnesi]]
[[Category: Trematomus newnesi]]
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[[Category: Mazzarella, L.]]
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[[Category: Mazzarella L]]
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[[Category: Savino, C.]]
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[[Category: Savino C]]
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[[Category: Vitagliano, L.]]
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[[Category: Vitagliano L]]
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[[Category: Zagari, A.]]
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[[Category: Zagari A]]
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[[Category: hemoglobin]]
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[[Category: oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:49:54 2008''
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Current revision

CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN

PDB ID 1t1n

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