5uz0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5uz0" [edit=sysop:move=sysop])
Current revision (14:30, 6 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5uz0 is ON HOLD
+
==Crystal structure of AICARFT bound to an antifolate==
 +
<StructureSection load='5uz0' size='340' side='right'caption='[[5uz0]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5uz0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZ0 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8US:N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide'>8US</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uz0 OCA], [https://pdbe.org/5uz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uz0 RCSB], [https://www.ebi.ac.uk/pdbsum/5uz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uz0 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PUR9_HUMAN PUR9_HUMAN] Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR) [MIM:[https://omim.org/entry/608688 608688]. A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness.<ref>PMID:14966129</ref> <ref>PMID:15114530</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PUR9_HUMAN PUR9_HUMAN] Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.<ref>PMID:14966129</ref>
-
Authors: Shane Atwell, Yong Wang, Kevin R. Fales, David Clawson, Jing Wang
+
==See Also==
-
 
+
*[[Bifunctional purine biosynthesis protein PURH|Bifunctional purine biosynthesis protein PURH]]
-
Description: Crystal structure of AICARFT bound to an antifolate.
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Shane Atwell, Yong Wang, Kevin R. Fales, David Clawson, Jing Wang]]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Atwell S]]
 +
[[Category: Clawson D]]
 +
[[Category: Fales KR]]
 +
[[Category: Wang J]]
 +
[[Category: Wang Y]]

Current revision

Crystal structure of AICARFT bound to an antifolate

PDB ID 5uz0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5uz0"
Personal tools