5uzs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P200== | |
| + | <StructureSection load='5uzs' size='340' side='right'caption='[[5uzs]], [[Resolution|resolution]] 2.37Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5uzs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_ATCC_13124 Clostridium perfringens ATCC 13124]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.367Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L4:3-(2-{[(4-CHLOROPHENYL)CARBAMOYL]AMINO}PROPAN-2-YL)-N-HYDROXYBENZENE-1-CARBOXIMIDAMIDE'>8L4</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uzs OCA], [https://pdbe.org/5uzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uzs RCSB], [https://www.ebi.ac.uk/pdbsum/5uzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uzs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0H2YRZ7_CLOP1 A0A0H2YRZ7_CLOP1] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
| - | + | ==See Also== | |
| - | + | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Clostridium perfringens ATCC 13124]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Anderson WF]] |
| - | [[Category: | + | [[Category: Gollapalli DR]] |
| - | [[Category: | + | [[Category: Gu M]] |
| - | [[Category: | + | [[Category: Hedstrom L]] |
| - | [[Category: | + | [[Category: Joachimiak A]] |
| - | [[Category: | + | [[Category: Kim Y]] |
| - | [[Category: | + | [[Category: Makowska-Grzyska M]] |
| - | [[Category: | + | [[Category: Maltseva N]] |
| + | [[Category: Mulligan R]] | ||
Current revision
Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P200
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