5x57

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(New page: '''Unreleased structure''' The entry 5x57 is ON HOLD Authors: Yang, F., Wang, T., Zhang, Y., Wu, X.Y. Description: Structure of GAR domain of ACF7 Category: Unreleased Structures [...)
Current revision (10:17, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5x57 is ON HOLD
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==Structure of GAR domain of ACF7==
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<StructureSection load='5x57' size='340' side='right'caption='[[5x57]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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Authors: Yang, F., Wang, T., Zhang, Y., Wu, X.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X57 FirstGlance]. <br>
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Description: Structure of GAR domain of ACF7
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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[[Category: Wang, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x57 OCA], [https://pdbe.org/5x57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x57 RCSB], [https://www.ebi.ac.uk/pdbsum/5x57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x57 ProSAT]</span></td></tr>
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[[Category: Zhang, Y]]
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</table>
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[[Category: Wu, X.Y]]
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== Function ==
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[[Category: Yang, F]]
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[https://www.uniprot.org/uniprot/MACF1_HUMAN MACF1_HUMAN] Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).<ref>PMID:15265687</ref> <ref>PMID:20937854</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Wang T]]
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[[Category: Wu XY]]
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[[Category: Yang F]]
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[[Category: Zhang Y]]

Current revision

Structure of GAR domain of ACF7

PDB ID 5x57

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OCA

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