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5l22

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==PrtD T1SS ABC transporter==
==PrtD T1SS ABC transporter==
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<StructureSection load='5l22' size='340' side='right' caption='[[5l22]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='5l22' size='340' side='right'caption='[[5l22]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l22]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L22 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L22 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l22 OCA], [http://pdbe.org/5l22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l22 RCSB], [http://www.ebi.ac.uk/pdbsum/5l22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l22 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l22 OCA], [https://pdbe.org/5l22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l22 RCSB], [https://www.ebi.ac.uk/pdbsum/5l22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l22 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O67184_AQUAE O67184_AQUAE]
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Type-1 secretion systems (T1SSs) represent a widespread mode of protein secretion across the cell envelope in Gram-negative bacteria. The T1SS is composed of an inner-membrane ABC transporter, a periplasmic membrane-fusion protein, and an outer-membrane porin. These three components assemble into a complex spanning both membranes and providing a conduit for the translocation of unfolded polypeptides. We show that ATP hydrolysis and assembly of the entire T1SS complex is necessary for protein secretion. Furthermore, we present a 3.15-A crystal structure of AaPrtD, the ABC transporter found in the Aquifex aeolicus T1SS. The structure suggests a substrate entry window just above the transporter's nucleotide binding domains. In addition, highly kinked transmembrane helices, which frame a narrow channel not observed in canonical peptide transporters, are likely involved in substrate translocation. Overall, the AaPrtD structure supports a polypeptide transport mechanism distinct from alternating access.
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Structure of a Type-1 Secretion System ABC Transporter.,Morgan JL, Acheson JF, Zimmer J Structure. 2017 Mar 7;25(3):522-529. doi: 10.1016/j.str.2017.01.010. Epub 2017, Feb 16. PMID:28216041<ref>PMID:28216041</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5l22" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Morgan, J L.W]]
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Zimmer, J]]
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[[Category: Large Structures]]
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[[Category: Abc transporter]]
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[[Category: Morgan JLW]]
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[[Category: Atpase]]
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[[Category: Zimmer J]]
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[[Category: Protein transport]]
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[[Category: Secretion]]
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[[Category: T1ss]]
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Current revision

PrtD T1SS ABC transporter

PDB ID 5l22

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