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4g5d
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==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH== | ==X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH== | ||
| - | <StructureSection load='4g5d' size='340' side='right' caption='[[4g5d]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='4g5d' size='340' side='right'caption='[[4g5d]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4g5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major_strain_Friedlin Leishmania major strain Friedlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G5D FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5d OCA], [https://pdbe.org/4g5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g5d RCSB], [https://www.ebi.ac.uk/pdbsum/4g5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5d ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref> |
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==See Also== | ==See Also== | ||
| - | *[[Prostaglandin F synthase|Prostaglandin F synthase]] | + | *[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Leishmania major strain Friedlin]] |
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Current revision
X-ray crystal structure of Prostaglandin f synthase from Leishmania major Friedlin bound to NADPH
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