This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4xpa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:47, 27 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine==
==X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine==
-
<StructureSection load='4xpa' size='340' side='right' caption='[[4xpa]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
+
<StructureSection load='4xpa' size='340' side='right'caption='[[4xpa]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4xpa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPA FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4xpa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XPA FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=42J:2-(3,4-DICHLOROPHENYL)ETHANAMINE'>42J</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=N9S:4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSE'>N9S</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xnu|4xnu]], [[4xnx|4xnx]], [[4xp1|4xp1]], [[4xp4|4xp4]], [[4xp5|4xp5]], [[4xp6|4xp6]], [[4xp9|4xp9]], [[4xpb|4xpb]], [[4xpf|4xpf]], [[4xpg|4xpg]], [[4xph|4xph]], [[4xpt|4xpt]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42J:2-(3,4-DICHLOROPHENYL)ETHANAMINE'>42J</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRD_900018:beta-maltose'>PRD_900018</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpa OCA], [http://pdbe.org/4xpa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpa RCSB], [http://www.ebi.ac.uk/pdbsum/4xpa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpa ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpa OCA], [https://pdbe.org/4xpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xpa RCSB], [https://www.ebi.ac.uk/pdbsum/4xpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpa ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DAT_DROME DAT_DROME] Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:11125028, PubMed:12606774, PubMed:24037379, PubMed:25970245). Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin (PubMed:11125028, PubMed:12606774). Plays a role in the regulation of the rest/activity cycle (PubMed:16093388, PubMed:25232310).<ref>PMID:11125028</ref> <ref>PMID:12606774</ref> <ref>PMID:16093388</ref> <ref>PMID:24037379</ref> <ref>PMID:25232310</ref> <ref>PMID:25970245</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 21:
==See Also==
==See Also==
-
*[[3D structures of antibody|3D structures of antibody]]
+
*[[Antibody 3D structures|Antibody 3D structures]]
 +
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Aravind, P]]
+
[[Category: Drosophila melanogaster]]
-
[[Category: Gouaux, E]]
+
[[Category: Large Structures]]
-
[[Category: Wang, K]]
+
[[Category: Mus musculus]]
-
[[Category: All-alpha helical antidepressant complex]]
+
[[Category: Aravind P]]
-
[[Category: Integral membrane protein]]
+
[[Category: Gouaux E]]
-
[[Category: Transport protein-inhibitor complex]]
+
[[Category: Wang K]]

Current revision

X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine

PDB ID 4xpa

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xpa"
Personal tools