4xxv

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==Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD==
==Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD==
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<StructureSection load='4xxv' size='340' side='right' caption='[[4xxv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4xxv' size='340' side='right'caption='[[4xxv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xxv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_thailandensis_E264 Burkholderia thailandensis E264]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XXV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iwh|4iwh]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxv OCA], [https://pdbe.org/4xxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xxv RCSB], [https://www.ebi.ac.uk/pdbsum/4xxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xxv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxv OCA], [http://pdbe.org/4xxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xxv RCSB], [http://www.ebi.ac.uk/pdbsum/4xxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xxv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEU3_BURTA LEU3_BURTA]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
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[https://www.uniprot.org/uniprot/LEU3_BURTA LEU3_BURTA] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-isopropylmalate dehydrogenase]]
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[[Category: Burkholderia thailandensis E264]]
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[[Category: Structural genomic]]
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[[Category: Large Structures]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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[[Category: Ssgcid]]
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Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD

PDB ID 4xxv

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