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5mc9

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==Crystal structure of the heterotrimeric integrin-binding region of laminin-111==
==Crystal structure of the heterotrimeric integrin-binding region of laminin-111==
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<StructureSection load='5mc9' size='340' side='right' caption='[[5mc9]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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<StructureSection load='5mc9' size='340' side='right'caption='[[5mc9]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mc9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MC9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mc9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MC9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mc9 OCA], [http://pdbe.org/5mc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mc9 RCSB], [http://www.ebi.ac.uk/pdbsum/5mc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mc9 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mc9 OCA], [https://pdbe.org/5mc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mc9 RCSB], [https://www.ebi.ac.uk/pdbsum/5mc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mc9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LAMA1_MOUSE LAMA1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. [[http://www.uniprot.org/uniprot/LAMC1_MOUSE LAMC1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. [[http://www.uniprot.org/uniprot/LAMB1_MOUSE LAMB1_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (By similarity). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity).
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[https://www.uniprot.org/uniprot/LAMA1_MOUSE LAMA1_MOUSE] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mc9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mc9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Laminin|Laminin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hohenester, E]]
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[[Category: Large Structures]]
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[[Category: Pulido, D]]
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[[Category: Mus musculus]]
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[[Category: Cell adhesion]]
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[[Category: Hohenester E]]
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[[Category: Coiled coil]]
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[[Category: Pulido D]]
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[[Category: Extracellular matrix]]
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[[Category: Laminin g-like domain]]
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Current revision

Crystal structure of the heterotrimeric integrin-binding region of laminin-111

PDB ID 5mc9

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