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5uj7

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==Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5==
==Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5==
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<StructureSection load='5uj7' size='340' side='right' caption='[[5uj7]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
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<StructureSection load='5uj7' size='340' side='right'caption='[[5uj7]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uj7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uj7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UJ7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.394&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uj8|5uj8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj7 OCA], [http://pdbe.org/5uj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj7 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj7 OCA], [https://pdbe.org/5uj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uj7 RCSB], [https://www.ebi.ac.uk/pdbsum/5uj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN]] Ear-patella-short stature syndrome. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/ORC4_HUMAN ORC4_HUMAN]] Ear-patella-short stature syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN] Ear-patella-short stature syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. [[http://www.uniprot.org/uniprot/ORC5_HUMAN ORC5_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. [[http://www.uniprot.org/uniprot/ORC4_HUMAN ORC4_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.<ref>PMID:22427655</ref>
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[https://www.uniprot.org/uniprot/ORC1_HUMAN ORC1_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Elkayam, E]]
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[[Category: Homo sapiens]]
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[[Category: Joshua-Tor, L]]
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[[Category: Large Structures]]
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[[Category: On, K F]]
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[[Category: Elkayam E]]
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[[Category: Tocilj, A]]
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[[Category: Joshua-Tor L]]
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[[Category: Aaa+ atpase]]
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[[Category: On KF]]
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[[Category: Dna binding protein]]
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[[Category: Tocilj A]]
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[[Category: Dna-binding]]
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[[Category: Replication]]
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Current revision

Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5

PDB ID 5uj7

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