5ak0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:41, 9 May 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Human PFKFB3 in complex with an indole inhibitor 6==
==Human PFKFB3 in complex with an indole inhibitor 6==
-
<StructureSection load='5ak0' size='340' side='right' caption='[[5ak0]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
+
<StructureSection load='5ak0' size='340' side='right'caption='[[5ak0]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ak0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AK0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ak0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AK0 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8V1:(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE'>8V1</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=PHS:PHOSPHONIC+ACID'>PHS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajv|5ajv]], [[5ajw|5ajw]], [[5ajx|5ajx]], [[5ajy|5ajy]], [[5ajz|5ajz]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8V1:(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE'>8V1</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=PHS:PHOSPHONIC+ACID'>PHS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ak0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak0 OCA], [http://pdbe.org/5ak0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ak0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ak0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ak0 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ak0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak0 OCA], [https://pdbe.org/5ak0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ak0 RCSB], [https://www.ebi.ac.uk/pdbsum/5ak0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ak0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.
+
[https://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN] Synthesis and degradation of fructose 2,6-bisphosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Boyd, S]]
+
[[Category: Homo sapiens]]
-
[[Category: Brookfield, J L]]
+
[[Category: Large Structures]]
-
[[Category: Critchlow, S E]]
+
[[Category: Boyd S]]
-
[[Category: Cumming, I A]]
+
[[Category: Brookfield JL]]
-
[[Category: Curtis, N J]]
+
[[Category: Critchlow SE]]
-
[[Category: Debreczeni, J E]]
+
[[Category: Cumming IA]]
-
[[Category: Degorce, S L]]
+
[[Category: Curtis NJ]]
-
[[Category: Donald, C]]
+
[[Category: Debreczeni JE]]
-
[[Category: Evans, N J]]
+
[[Category: Degorce SL]]
-
[[Category: Groombridge, S]]
+
[[Category: Donald C]]
-
[[Category: Hopcroft, P]]
+
[[Category: Evans NJ]]
-
[[Category: Jones, N P]]
+
[[Category: Groombridge S]]
-
[[Category: Kettle, J G]]
+
[[Category: Hopcroft P]]
-
[[Category: Lamont, S]]
+
[[Category: Jones NP]]
-
[[Category: Lewis, H J]]
+
[[Category: Kettle JG]]
-
[[Category: MacFaull, P]]
+
[[Category: Lamont S]]
-
[[Category: McLoughlin, S B]]
+
[[Category: Lewis HJ]]
-
[[Category: Rigoreau, L J.M]]
+
[[Category: MacFaull P]]
-
[[Category: Smith, J M]]
+
[[Category: McLoughlin SB]]
-
[[Category: St-Gallay, S]]
+
[[Category: Rigoreau LJM]]
-
[[Category: Stock, J K]]
+
[[Category: Smith JM]]
-
[[Category: Wheatley, E R]]
+
[[Category: St-Gallay S]]
-
[[Category: Wingfield, J]]
+
[[Category: Stock JK]]
-
[[Category: Winter, J]]
+
[[Category: Wheatley ER]]
-
[[Category: Transferase]]
+
[[Category: Wingfield J]]
 +
[[Category: Winter J]]

Current revision

Human PFKFB3 in complex with an indole inhibitor 6

PDB ID 5ak0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ak0"
Personal tools