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4yir

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==Crystal structure of Rad4-Rad23 crosslinked to an undamaged DNA==
==Crystal structure of Rad4-Rad23 crosslinked to an undamaged DNA==
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<StructureSection load='4yir' size='340' side='right' caption='[[4yir]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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<StructureSection load='4yir' size='340' side='right'caption='[[4yir]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yir]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4u29 4u29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YIR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4u29 4u29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YIR FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=G47:N2-ETHANETHIOL-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>G47</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0501&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u29|4u29]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G47:N2-ETHANETHIOL-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>G47</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yir OCA], [http://pdbe.org/4yir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yir RCSB], [http://www.ebi.ac.uk/pdbsum/4yir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yir ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yir OCA], [https://pdbe.org/4yir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yir RCSB], [https://www.ebi.ac.uk/pdbsum/4yir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yir ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST]] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. [[http://www.uniprot.org/uniprot/RAD23_YEAST RAD23_YEAST]] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
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[https://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yir" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yir" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA repair protein Rad4|DNA repair protein Rad4]]
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*[[UV excision repair protein|UV excision repair protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, X]]
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[[Category: Large Structures]]
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[[Category: Kim, Y]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Min, J H]]
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[[Category: Synthetic construct]]
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[[Category: Beta-hairpin]]
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[[Category: Chen X]]
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[[Category: Disulfide crosslinking]]
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[[Category: Kim Y]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Min J-H]]
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[[Category: Dna damage repair]]
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[[Category: Nucleotide excision repair]]
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[[Category: Protein-dna complex]]
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[[Category: Protein-dna crosslinking]]
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[[Category: Protein-dna interaction]]
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[[Category: Transglutaminase domain]]
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[[Category: Xeroderma pigmentosum]]
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Current revision

Crystal structure of Rad4-Rad23 crosslinked to an undamaged DNA

PDB ID 4yir

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