4yno

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==Crystal structure of MAPK13 at INACTIVE FORM==
==Crystal structure of MAPK13 at INACTIVE FORM==
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<StructureSection load='4yno' size='340' side='right' caption='[[4yno]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4yno' size='340' side='right'caption='[[4yno]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yno]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4exu 4exu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YNO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yno]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4exu 4exu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YNO FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4myg|4myg]], [[4eyj|4eyj]], [[4eym|4eym]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yno OCA], [https://pdbe.org/4yno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yno RCSB], [https://www.ebi.ac.uk/pdbsum/4yno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yno ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yno OCA], [http://pdbe.org/4yno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yno RCSB], [http://www.ebi.ac.uk/pdbsum/4yno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yno ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MK13_HUMAN MK13_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.<ref>PMID:9731215</ref> <ref>PMID:11500363</ref> <ref>PMID:11943212</ref> <ref>PMID:15632108</ref> <ref>PMID:17256148</ref> <ref>PMID:18006338</ref> <ref>PMID:18367666</ref> <ref>PMID:20478268</ref>
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[https://www.uniprot.org/uniprot/MK13_HUMAN MK13_HUMAN] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.<ref>PMID:9731215</ref> <ref>PMID:11500363</ref> <ref>PMID:11943212</ref> <ref>PMID:15632108</ref> <ref>PMID:17256148</ref> <ref>PMID:18006338</ref> <ref>PMID:18367666</ref> <ref>PMID:20478268</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
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*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mitogen-activated protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Brett, T J]]
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[[Category: Large Structures]]
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[[Category: Miller, C A]]
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[[Category: Brett TJ]]
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[[Category: P38 kinase]]
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[[Category: Miller CA]]
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[[Category: Transferase]]
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Current revision

Crystal structure of MAPK13 at INACTIVE FORM

PDB ID 4yno

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