5g1z
From Proteopedia
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==Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 1)== | ==Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 1)== | ||
| - | <StructureSection load='5g1z' size='340' side='right' caption='[[5g1z]], [[Resolution|resolution]] 1.50Å' scene=''> | + | <StructureSection load='5g1z' size='340' side='right'caption='[[5g1z]], [[Resolution|resolution]] 1.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5g1z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G1Z OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5g1z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G1Z FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U53:ETHYL+4-(2-CYANOETHYLSULFANYL)-6-METHOXY-QUINOLINE-3-CARBOXYLATE'>U53</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U53:ETHYL+4-(2-CYANOETHYLSULFANYL)-6-METHOXY-QUINOLINE-3-CARBOXYLATE'>U53</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g1z OCA], [https://pdbe.org/5g1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g1z RCSB], [https://www.ebi.ac.uk/pdbsum/5g1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g1z ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586] |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a potential target for the treatment of this disease. Herein, we report the synthesis and the structure-guided optimization of a series of quinolines with balanced activity against both Plasmodium vivax and Plasmodium falciparum N-myristoyltransferase (NMT). | ||
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| + | Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.,Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW Medchemcomm. 2017 Jan 1;8(1):191-197. doi: 10.1039/c6md00531d. Epub 2016 Nov 11. PMID:28626547<ref>PMID:28626547</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5g1z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bell | + | [[Category: Plasmodium vivax]] |
| - | [[Category: Brannigan | + | [[Category: Bell AS]] |
| - | [[Category: Goncalves | + | [[Category: Brannigan JA]] |
| - | [[Category: Laporte | + | [[Category: Goncalves V]] |
| - | [[Category: Leatherbarrow | + | [[Category: Laporte A]] |
| - | [[Category: Roberts | + | [[Category: Leatherbarrow RJ]] |
| - | [[Category: Tate | + | [[Category: Roberts SM]] |
| - | [[Category: Wilkinson | + | [[Category: Tate EW]] |
| - | + | [[Category: Wilkinson AJ]] | |
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Current revision
Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 1)
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