5gpc
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==Structural analysis of fatty acid degradation regulator FadR from Bacillus halodurans== | ==Structural analysis of fatty acid degradation regulator FadR from Bacillus halodurans== | ||
| - | <StructureSection load='5gpc' size='340' side='right' caption='[[5gpc]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='5gpc' size='340' side='right'caption='[[5gpc]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5gpc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPC OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5gpc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Alkalihalobacillus_halodurans_C-125 Alkalihalobacillus halodurans C-125] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gpc OCA], [https://pdbe.org/5gpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gpc RCSB], [https://www.ebi.ac.uk/pdbsum/5gpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gpc ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9K8A4_HALH5 Q9K8A4_HALH5] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | FadR is a fatty acyl-CoA dependent transcription factor that regulates genes encoding proteins involved in fatty-acid degradation and synthesis pathways. In this study, the crystal structures of Bacillus halodurans FadR, which belong to the TetR family, have been determined in three different forms: ligand-bound, ligand-free and DNA-bound at resolutions of 1.75, 2.05 and 2.80 A, respectively. Structural and functional data showed that B. halodurans FadR was bound to its operator site without fatty acyl-CoAs. Structural comparisons among the three different forms of B. halodurans FadR revealed that the movement of DNA binding domains toward the operator DNA was blocked upon binding of ligand molecules. These findings suggest that the TetR family FadR negatively regulates the genes involved in fatty acid metabolism by binding cooperatively to the operator DNA as a dimer of dimers. | ||
| + | |||
| + | Structural basis of operator sites recognition and effector binding in the TetR family transcription regulator FadR.,Yeo HK, Park YW, Lee JY Nucleic Acids Res. 2017 Apr 20;45(7):4244-4254. doi: 10.1093/nar/gkx009. PMID:28160603<ref>PMID:28160603</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5gpc" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | ||
| + | *[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Alkalihalobacillus halodurans C-125]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Lee JY]] |
| - | [[Category: | + | [[Category: Park TW]] |
| - | [[Category: | + | [[Category: Yeo HK]] |
| - | + | ||
Current revision
Structural analysis of fatty acid degradation regulator FadR from Bacillus halodurans
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