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5ka9

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==Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state==
==Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state==
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<StructureSection load='5ka9' size='340' side='right' caption='[[5ka9]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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<StructureSection load='5ka9' size='340' side='right'caption='[[5ka9]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ka9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KA9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ka9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KA9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OTA:2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC+ACID'>OTA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k9v|5k9v]], [[5k9w|5k9w]], [[5ka0|5ka0]], [[5ka1|5ka1]], [[5ka2|5ka2]], [[5ka3|5ka3]], [[5ka4|5ka4]], [[5ka7|5ka7]], [[5ka8|5ka8]], [[5kaa|5kaa]], [[5kab|5kab]], [[5kac|5kac]], [[5kad|5kad]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OTA:2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC+ACID'>OTA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ka9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ka9 OCA], [https://pdbe.org/5ka9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ka9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ka9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ka9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ka9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ka9 OCA], [http://pdbe.org/5ka9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ka9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ka9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ka9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ka9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ka9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Choy, M S]]
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[[Category: Large Structures]]
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[[Category: Page, R]]
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[[Category: Choy MS]]
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[[Category: Peti, W]]
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[[Category: Page R]]
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[[Category: Hydrolase]]
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[[Category: Peti W]]
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[[Category: Protein tyrosine phosphatase]]
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Current revision

Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state

PDB ID 5ka9

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