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5udl

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==IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap)==
==IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap)==
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<StructureSection load='5udl' size='340' side='right' caption='[[5udl]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='5udl' size='340' side='right'caption='[[5udl]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5udl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5udl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UDL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5udi|5udi]], [[5udj|5udj]], [[5udk|5udk]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5udl OCA], [https://pdbe.org/5udl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5udl RCSB], [https://www.ebi.ac.uk/pdbsum/5udl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5udl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5udl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5udl OCA], [http://pdbe.org/5udl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5udl RCSB], [http://www.ebi.ac.uk/pdbsum/5udl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5udl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN]] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref>
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[https://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abbas, Y M]]
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[[Category: Homo sapiens]]
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[[Category: Damha, M J]]
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[[Category: Large Structures]]
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[[Category: Martinez-Montero, S]]
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[[Category: Unidentified]]
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[[Category: Nagar, B]]
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[[Category: Abbas YM]]
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[[Category: Mrna cap]]
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[[Category: Damha MJ]]
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[[Category: N7-methylguanosine-triphosphate rna]]
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[[Category: Martinez-Montero S]]
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[[Category: Rna binding protein]]
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[[Category: Nagar B]]
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[[Category: Tetratricopeptide repeat]]
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Current revision

IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap)

PDB ID 5udl

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