5if5

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==Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol==
==Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol==
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<StructureSection load='5if5' size='340' side='right' caption='[[5if5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='5if5' size='340' side='right'caption='[[5if5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5if5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IF5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5if5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Wilson-Smith/1933(H1N1)) Influenza A virus (A/Wilson-Smith/1933(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IF5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6B0:(2,3-DICHLOROPHENYL)METHANOL'>6B0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iuj|4iuj]], [[5ieq|5ieq]], [[5if2|5if2]], [[5if4|5if4]], [[5if7|5if7]], [[5if8|5if8]], [[5ifb|5ifb]], [[5ifc|5ifc]], [[5ifd|5ifd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6B0:(2,3-DICHLOROPHENYL)METHANOL'>6B0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5if5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5if5 OCA], [http://pdbe.org/5if5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5if5 RCSB], [http://www.ebi.ac.uk/pdbsum/5if5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5if5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5if5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5if5 OCA], [https://pdbe.org/5if5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5if5 RCSB], [https://www.ebi.ac.uk/pdbsum/5if5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5if5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA_I33A0 PA_I33A0]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication.
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[https://www.uniprot.org/uniprot/PA_I33A0 PA_I33A0] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication.
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Structural genomic]]
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[[Category: Large Structures]]
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[[Category: Flu]]
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[[Category: Fragment screening]]
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[[Category: Niaid]]
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[[Category: Ssgcid]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol

PDB ID 5if5

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