5thm

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==Esterase-6 from Drosophila melanogaster==
==Esterase-6 from Drosophila melanogaster==
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<StructureSection load='5thm' size='340' side='right' caption='[[5thm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='5thm' size='340' side='right'caption='[[5thm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5thm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5THM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5thm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5THM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BZ:N,N-DIMETHYLBORANAMINE'>7BZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7BZ:N,N-DIMETHYLBORANAMINE'>7BZ</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5thm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thm OCA], [https://pdbe.org/5thm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5thm RCSB], [https://www.ebi.ac.uk/pdbsum/5thm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5thm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5thm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thm OCA], [http://pdbe.org/5thm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5thm RCSB], [http://www.ebi.ac.uk/pdbsum/5thm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5thm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EST6_DROME EST6_DROME]] Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology.
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[https://www.uniprot.org/uniprot/EST6_DROME EST6_DROME] Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate.
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Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.,Younus F, Fraser NJ, Coppin CW, Liu JW, Correy GJ, Chertemps T, Pandey G, Maibeche M, Jackson CJ, Oakeshott JG Sci Rep. 2017 Apr 10;7:46188. doi: 10.1038/srep46188. PMID:28393888<ref>PMID:28393888</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5thm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Carboxylesterase 3D structures|Carboxylesterase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carboxylesterase]]
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[[Category: Drosophila melanogaster]]
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[[Category: Fraser, N J]]
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[[Category: Large Structures]]
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[[Category: Jackson, C J]]
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[[Category: Fraser NJ]]
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[[Category: Hydrolase]]
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[[Category: Jackson CJ]]

Current revision

Esterase-6 from Drosophila melanogaster

PDB ID 5thm

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