Atlastin

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<StructureSection load='4ido' size='350' side='right' caption='Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code [[4ido]]).' scene='59/590828/Cv/1'>
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<StructureSection load='4ido' size='350' side='right' caption='Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code [[4ido]]).' scene='59/590828/Cv/7'>
== Function ==
== Function ==
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== Disease ==
== Disease ==
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Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D.
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Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. Mutations in ATL-3 affect multiple ER-related pathways<ref>PMID:30666337</ref>.
== Structural highlights ==
== Structural highlights ==
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*<scene name='59/590828/Cv/5'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref name="Ad">PMID:23334294</ref>
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*<scene name='59/590828/Cv/6'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref name="Ad">PMID:23334294</ref> Water molecules shown as red spheres.
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</StructureSection>
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==3D structures of atlastin==
==3D structures of atlastin==
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[[Atlastin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hATN cytoplasmic domain + GDP – human<br />
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[[4idn]] – hATN cytoplasmic domain + GNP <br />
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[[4idp]] – hATN cytoplasmic domain (mutant) + GNP <br />
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[[4ido]] – hATN cytoplasmic domain + GDP + AlF4<br />
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[[4idq]] – hATN cytoplasmic domain (mutant) + GDP + AlF4<br />
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[[3x1d]] – ATN + GDP – ''Drosophila melanogaster''<br />
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== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code 4ido).

Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353
  2. ↑ Behrendt L, Kurth I, Kaether C. A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways. Cell Mol Life Sci. 2019 Apr;76(7):1433-1445. doi: 10.1007/s00018-019-03010-x., Epub 2019 Jan 21. PMID:30666337 doi:http://dx.doi.org/10.1007/s00018-019-03010-x

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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