1tg8

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[[Image:1tg8.gif|left|200px]]
 
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{{Structure
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==The structure of Dengue virus E glycoprotein==
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|PDB= 1tg8 |SIZE=350|CAPTION= <scene name='initialview01'>1tg8</scene>, resolution 2.61&Aring;
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<StructureSection load='1tg8' size='340' side='right'caption='[[1tg8]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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<table><tr><td colspan='2'>[[1tg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TG8 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg8 OCA], [https://pdbe.org/1tg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1tg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg8 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1tge|1TGE]], [[1thd|1THD]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg8 OCA], [http://www.ebi.ac.uk/pdbsum/1tg8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tg8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/POLG_DEN2T POLG_DEN2T] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity).
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<div style="background-color:#fffaf0;">
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'''The structure of Dengue virus E glycoprotein'''
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== Publication Abstract from PubMed ==
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==Overview==
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Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
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==About this Structure==
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Conformational changes of the flavivirus E glycoprotein.,Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG Structure. 2004 Sep;12(9):1607-18. PMID:15341726<ref>PMID:15341726</ref>
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1TG8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG8 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Conformational changes of the flavivirus E glycoprotein., Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG, Structure. 2004 Sep;12(9):1607-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341726 15341726]
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</div>
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<div class="pdbe-citations 1tg8" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, T S.]]
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[[Category: Baker TS]]
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[[Category: Clements, D.]]
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[[Category: Clements D]]
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[[Category: Ogata, S.]]
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[[Category: Ogata S]]
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[[Category: Rossmann, M G.]]
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[[Category: Rossmann MG]]
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[[Category: Strauss, J H.]]
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[[Category: Strauss JH]]
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[[Category: Zhang, W.]]
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[[Category: Zhang W]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: flavivirus e conformation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:55:41 2008''
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Current revision

The structure of Dengue virus E glycoprotein

PDB ID 1tg8

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OCA

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