1tgy

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[[Image:1tgy.gif|left|200px]]
 
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{{Structure
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==Structure of E. coli Uridine Phosphorylase complexed with uracil and ribose 1-phosphate==
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|PDB= 1tgy |SIZE=350|CAPTION= <scene name='initialview01'>1tgy</scene>, resolution 2.20&Aring;
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<StructureSection load='1tgy' size='340' side='right'caption='[[1tgy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene>
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<table><tr><td colspan='2'>[[1tgy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGY FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE= UDP, B3831 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=R1P:RIBOSE-1-PHOSPHATE'>R1P</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgy OCA], [https://pdbe.org/1tgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgy RCSB], [https://www.ebi.ac.uk/pdbsum/1tgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgy ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1k3f|1K3F]], [[1lx7|1LX7]], [[1rxc|1RXC]], [[1rxs|1RXS]], [[1rxu|1RXU]], [[1rxy|1RXY]], [[1tgv|1TGV]], [[1tgw|1TGW]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgy OCA], [http://www.ebi.ac.uk/pdbsum/1tgy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tgy RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/UDP_ECOLI UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgy ConSurf].
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<div style="clear:both"></div>
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'''Structure of E. coli Uridine Phosphorylase complexed with uracil and ribose 1-phosphate'''
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==See Also==
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1TGY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGY OCA].
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Uridine phosphorylase]]
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[[Category: Begley TP]]
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[[Category: Begley, T P.]]
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[[Category: Bu W]]
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[[Category: Bu, W.]]
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[[Category: Ealick SE]]
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[[Category: Ealick, S E.]]
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[[Category: Sanders JM]]
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[[Category: Sanders, J M.]]
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[[Category: Settembre EC]]
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[[Category: Settembre, E C.]]
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[[Category: pyrimidine nucleoside phosphorylase]]
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[[Category: uridine]]
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[[Category: uridine phosphorylase]]
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[[Category: uridine salvage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:55:56 2008''
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Current revision

Structure of E. coli Uridine Phosphorylase complexed with uracil and ribose 1-phosphate

PDB ID 1tgy

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