5ubb

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'''Unreleased structure'''
 
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The entry 5ubb is ON HOLD
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==Crystal structure of human alpha N-terminal protein methyltransferase 1B==
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<StructureSection load='5ubb' size='340' side='right'caption='[[5ubb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Dong, C., Zhu, L., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ubb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UBB FirstGlance]. <br>
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Description: Crystal structure of human alpha N-terminal protein methyltransferase 1B
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ubb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubb OCA], [https://pdbe.org/5ubb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ubb RCSB], [https://www.ebi.ac.uk/pdbsum/5ubb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubb ProSAT]</span></td></tr>
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[[Category: Dong, A]]
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</table>
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[[Category: Dong, C]]
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== Function ==
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[[Category: Min, J]]
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[https://www.uniprot.org/uniprot/NTM1B_HUMAN NTM1B_HUMAN] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.<ref>PMID:24090352</ref>
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[[Category: Edwards, A.M]]
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== References ==
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[[Category: Structural Genomics Consortium (Sgc)]]
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<references/>
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[[Category: Bountra, C]]
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__TOC__
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[[Category: Tempel, W]]
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</StructureSection>
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[[Category: Zhu, L]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Dong A]]
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[[Category: Dong C]]
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[[Category: Edwards AM]]
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[[Category: Min J]]
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[[Category: Tempel W]]
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[[Category: Zhu L]]

Current revision

Crystal structure of human alpha N-terminal protein methyltransferase 1B

PDB ID 5ubb

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