5uz0

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'''Unreleased structure'''
 
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The entry 5uz0 is ON HOLD
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==Crystal structure of AICARFT bound to an antifolate==
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<StructureSection load='5uz0' size='340' side='right'caption='[[5uz0]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5uz0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZ0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8US:N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide'>8US</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uz0 OCA], [https://pdbe.org/5uz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uz0 RCSB], [https://www.ebi.ac.uk/pdbsum/5uz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uz0 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PUR9_HUMAN PUR9_HUMAN] Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR) [MIM:[https://omim.org/entry/608688 608688]. A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness.<ref>PMID:14966129</ref> <ref>PMID:15114530</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PUR9_HUMAN PUR9_HUMAN] Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.<ref>PMID:14966129</ref>
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Authors: Atwell, S., Wang, Y., Fales, K.R., Clawson, D., Wang, J.
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==See Also==
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*[[Bifunctional purine biosynthesis protein PURH|Bifunctional purine biosynthesis protein PURH]]
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Description: Crystal structure of AICARFT bound to an antifolate
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Clawson, D]]
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__TOC__
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[[Category: Atwell, S]]
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</StructureSection>
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[[Category: Wang, Y]]
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[[Category: Homo sapiens]]
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[[Category: Fales, K.R]]
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[[Category: Large Structures]]
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[[Category: Wang, J]]
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[[Category: Atwell S]]
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[[Category: Clawson D]]
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[[Category: Fales KR]]
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[[Category: Wang J]]
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[[Category: Wang Y]]

Current revision

Crystal structure of AICARFT bound to an antifolate

PDB ID 5uz0

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