5wwv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of porcine kidney D-amino acid oxidase mutant (I230A/R283G)== | |
| + | <StructureSection load='5wwv' size='340' side='right'caption='[[5wwv]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5wwv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WWV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7V3:(S)-(4-chlorophenyl)-phenyl-methanamine'>7V3</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwv OCA], [https://pdbe.org/5wwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wwv RCSB], [https://www.ebi.ac.uk/pdbsum/5wwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | ||
| - | + | ==See Also== | |
| - | + | *[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Asano | + | [[Category: Sus scrofa]] |
| - | [[Category: Ohno | + | [[Category: Asano Y]] |
| - | [[Category: | + | [[Category: Motojima F]] |
| + | [[Category: Ohno A]] | ||
| + | [[Category: Yasukawa K]] | ||
Current revision
Crystal structure of porcine kidney D-amino acid oxidase mutant (I230A/R283G)
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