1tlr

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[[Image:1tlr.jpg|left|200px]]
 
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{{Structure
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==SOLUTION STRUCTURE OF TETRALOOP RECEPTOR RNA, NMR, 20 STRUCTURES==
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|PDB= 1tlr |SIZE=350|CAPTION= <scene name='initialview01'>1tlr</scene>
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<StructureSection load='1tlr' size='340' side='right'caption='[[1tlr]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1tlr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLR FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlr OCA], [https://pdbe.org/1tlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlr RCSB], [https://www.ebi.ac.uk/pdbsum/1tlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlr ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlr OCA], [http://www.ebi.ac.uk/pdbsum/1tlr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tlr RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''SOLUTION STRUCTURE OF TETRALOOP RECEPTOR RNA, NMR, 20 STRUCTURES'''
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==Overview==
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The GAAA tetraloop receptor is an 11-nucleotide RNA sequence that participates in the tertiary folding of a variety of large catalytic RNAs by providing a specific binding site for GAAA tetraloops. Here we report the solution structure of the isolated tetraloop receptor as solved by multidimensional, heteronuclear magnetic resonance spectroscopy. The internal loop of the tetraloop receptor has three adenosines stacked in a cross-strand or zipper-like fashion. This arrangement produces a high degree of base stacking within the asymmetric internal loop without extrahelical bases or kinking the helix. Additional interactions within the internal loop include a U. U mismatch pair and a G.U wobble pair. A comparison with the crystal structure of the receptor RNA bound to its tetraloop shows that a conformational change has to occur upon tetraloop binding, which is in good agreement with previous biochemical data. A model for an alternative binding site within the receptor is proposed based on the NMR structure, phylogenetic data and previous crystallographic structures of tetraloop interactions.
The GAAA tetraloop receptor is an 11-nucleotide RNA sequence that participates in the tertiary folding of a variety of large catalytic RNAs by providing a specific binding site for GAAA tetraloops. Here we report the solution structure of the isolated tetraloop receptor as solved by multidimensional, heteronuclear magnetic resonance spectroscopy. The internal loop of the tetraloop receptor has three adenosines stacked in a cross-strand or zipper-like fashion. This arrangement produces a high degree of base stacking within the asymmetric internal loop without extrahelical bases or kinking the helix. Additional interactions within the internal loop include a U. U mismatch pair and a G.U wobble pair. A comparison with the crystal structure of the receptor RNA bound to its tetraloop shows that a conformational change has to occur upon tetraloop binding, which is in good agreement with previous biochemical data. A model for an alternative binding site within the receptor is proposed based on the NMR structure, phylogenetic data and previous crystallographic structures of tetraloop interactions.
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==About this Structure==
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Solution structure of a GAAA tetraloop receptor RNA.,Butcher SE, Dieckmann T, Feigon J EMBO J. 1997 Dec 15;16(24):7490-9. PMID:9405377<ref>PMID:9405377</ref>
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1TLR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLR OCA].
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==Reference==
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Solution structure of a GAAA tetraloop receptor RNA., Butcher SE, Dieckmann T, Feigon J, EMBO J. 1997 Dec 15;16(24):7490-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9405377 9405377]
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[[Category: Protein complex]]
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[[Category: Butcher, S E.]]
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[[Category: Dieckmann, T.]]
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[[Category: Feigon, J.]]
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[[Category: group i intron]]
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[[Category: group ii intron]]
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[[Category: ribonucleic acid]]
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[[Category: tetraloop receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:57:57 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1tlr" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Butcher SE]]
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[[Category: Dieckmann T]]
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[[Category: Feigon J]]

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SOLUTION STRUCTURE OF TETRALOOP RECEPTOR RNA, NMR, 20 STRUCTURES

PDB ID 1tlr

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