5jv2

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==Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-055==
==Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-055==
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<StructureSection load='5jv2' size='340' side='right' caption='[[5jv2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5jv2' size='340' side='right'caption='[[5jv2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jv2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JV2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JV2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O3:{[6-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-5-YL]METHYL}PHOSPHONIC+ACID'>6O3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jv1|5jv1]], [[5jv0|5jv0]], [[5juz|5juz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6O3:{[6-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-5-YL]METHYL}PHOSPHONIC+ACID'>6O3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv2 OCA], [http://pdbe.org/5jv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv2 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv2 OCA], [https://pdbe.org/5jv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jv2 RCSB], [https://www.ebi.ac.uk/pdbsum/5jv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jv2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jv2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Berghuis, A M]]
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[[Category: Homo sapiens]]
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[[Category: Magder, A]]
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[[Category: Large Structures]]
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[[Category: Park, J]]
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[[Category: Berghuis AM]]
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[[Category: Tsakos, M]]
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[[Category: Magder A]]
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[[Category: Tsantrizos, Y S]]
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[[Category: Park J]]
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[[Category: Transferase]]
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[[Category: Tsakos M]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Tsantrizos YS]]

Current revision

Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-055

PDB ID 5jv2

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