This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5jv0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:09, 20 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038==
==Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038==
-
<StructureSection load='5jv0' size='340' side='right' caption='[[5jv0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+
<StructureSection load='5jv0' size='340' side='right'caption='[[5jv0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5jv0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JV0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5jv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JV0 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL5:[(1R)-2-(3-FLUOROPHENYL)-1-{[6-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}ETHYL]PHOSPHONIC+ACID'>YL5</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jv2|5jv2]], [[5jv1|5jv1]], [[5juz|5juz]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL5:[(1R)-2-(3-FLUOROPHENYL)-1-{[6-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}ETHYL]PHOSPHONIC+ACID'>YL5</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv0 OCA], [http://pdbe.org/5jv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv0 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv0 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv0 OCA], [https://pdbe.org/5jv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jv0 RCSB], [https://www.ebi.ac.uk/pdbsum/5jv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5jv0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jv0" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Berghuis, A M]]
+
[[Category: Homo sapiens]]
-
[[Category: Leung, C Y]]
+
[[Category: Large Structures]]
-
[[Category: Park, J]]
+
[[Category: Berghuis AM]]
-
[[Category: Tsantrizos, Y S]]
+
[[Category: Leung CY]]
-
[[Category: Transferase]]
+
[[Category: Park J]]
-
[[Category: Transferase-transferase inhibitor complex]]
+
[[Category: Tsantrizos YS]]

Current revision

Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038

PDB ID 5jv0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5jv0"
Personal tools