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5u3f

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==Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative==
==Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative==
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<StructureSection load='5u3f' size='340' side='right' caption='[[5u3f]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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<StructureSection load='5u3f' size='340' side='right'caption='[[5u3f]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5u3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5u3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U3F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TS:(5-HYDROXY-6-METHYL-4-{[(3-OXO-2,3-DIHYDRO-1,2-OXAZOL-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>7TS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.695&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Branched-chain-amino-acid_transaminase Branched-chain-amino-acid transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.42 2.6.1.42] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TS:(5-HYDROXY-6-METHYL-4-{[(3-OXO-2,3-DIHYDRO-1,2-OXAZOL-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>7TS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3f OCA], [http://pdbe.org/5u3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3f RCSB], [http://www.ebi.ac.uk/pdbsum/5u3f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3f OCA], [https://pdbe.org/5u3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u3f RCSB], [https://www.ebi.ac.uk/pdbsum/5u3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ILVE_MYCTU ILVE_MYCTU]] Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val.<ref>PMID:20445230</ref>
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[https://www.uniprot.org/uniprot/ILVE_MYCTU ILVE_MYCTU] Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val.<ref>PMID:20445230</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5u3f" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5u3f" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Branched-chain-amino-acid transaminase]]
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[[Category: Large Structures]]
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[[Category: Blanchard, J S]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Favrot, L]]
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[[Category: Amorim Franco TM]]
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[[Category: Franco, T M.Amorim]]
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[[Category: Blanchard JS]]
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[[Category: Amino acid biosynthesis]]
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[[Category: Favrot L]]
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[[Category: Branched-chain amino acid transaminase]]
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[[Category: D-cycloserine]]
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[[Category: Inhibitor]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Transferase]]
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Current revision

Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative

PDB ID 5u3f

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