5ubb
From Proteopedia
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==Crystal structure of human alpha N-terminal protein methyltransferase 1B== | ==Crystal structure of human alpha N-terminal protein methyltransferase 1B== | ||
| - | <StructureSection load='5ubb' size='340' side='right' caption='[[5ubb]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='5ubb' size='340' side='right'caption='[[5ubb]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ubb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBB OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5ubb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UBB FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ubb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubb OCA], [https://pdbe.org/5ubb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ubb RCSB], [https://www.ebi.ac.uk/pdbsum/5ubb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubb ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NTM1B_HUMAN NTM1B_HUMAN] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.<ref>PMID:24090352</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Dong | + | [[Category: Bountra C]] |
| - | [[Category: Dong | + | [[Category: Dong A]] |
| - | [[Category: Edwards | + | [[Category: Dong C]] |
| - | [[Category: Min | + | [[Category: Edwards AM]] |
| - | + | [[Category: Min J]] | |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Zhu | + | [[Category: Zhu L]] |
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Current revision
Crystal structure of human alpha N-terminal protein methyltransferase 1B
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Dong A | Dong C | Edwards AM | Min J | Tempel W | Zhu L
