4ui1

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==Crystal structure of the human RGMC-BMP2 complex==
==Crystal structure of the human RGMC-BMP2 complex==
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<StructureSection load='4ui1' size='340' side='right' caption='[[4ui1]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='4ui1' size='340' side='right'caption='[[4ui1]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ui1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ui1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UI1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhy|4uhy]], [[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui2|4ui2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui1 OCA], [http://pdbe.org/4ui1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ui1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ui1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ui1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui1 OCA], [https://pdbe.org/4ui1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ui1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ui1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ui1 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Hemochromatosis type 2. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.[UniProtKB:Q7TQ32]
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[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Bone morphogenetic protein|Bone morphogenetic protein]]
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
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*[[Hemochromatosis protein|Hemochromatosis protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bell, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bishop, B]]
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[[Category: Large Structures]]
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[[Category: Elegheert, J]]
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[[Category: Bell CH]]
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[[Category: Healey, E G]]
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[[Category: Bishop B]]
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[[Category: Padilla-Parra, S]]
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[[Category: Elegheert J]]
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[[Category: Siebold, C]]
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[[Category: Healey EG]]
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[[Category: Axon guidance]]
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[[Category: Padilla-Parra S]]
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[[Category: Bone morphogenetic protein pathway]]
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[[Category: Siebold C]]
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[[Category: Cell surface receptor signaling]]
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[[Category: Hemojuvelin]]
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[[Category: Morphogen]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the human RGMC-BMP2 complex

PDB ID 4ui1

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