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4yzs

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==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==
==Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling==
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<StructureSection load='4yzs' size='340' side='right' caption='[[4yzs]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
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<StructureSection load='4yzs' size='340' side='right'caption='[[4yzs]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [http://pdbe.org/4yzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [http://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [https://pdbe.org/4yzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [https://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
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[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
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[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Ali, M M.U]]
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[[Category: Large Structures]]
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[[Category: Carrara, M]]
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[[Category: Ali MMU]]
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[[Category: Prischi, F]]
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[[Category: Carrara M]]
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[[Category: Er stress]]
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[[Category: Prischi F]]
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[[Category: Perk]]
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[[Category: Proteostasis]]
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[[Category: Signaling protein]]
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[[Category: Tetramer]]
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[[Category: Unfolded protein]]
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[[Category: Upr]]
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[[Category: Upr activation]]
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[[Category: Upr sensor]]
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Current revision

Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling

PDB ID 4yzs

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