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4ief

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==Complex of Porphyromonas gingivalis RgpB pro- and mature domains==
==Complex of Porphyromonas gingivalis RgpB pro- and mature domains==
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<StructureSection load='4ief' size='340' side='right' caption='[[4ief]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4ief' size='340' side='right'caption='[[4ief]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ief]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IEF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ief]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_W83 Porphyromonas gingivalis W83]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IEF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Gingipain_R Gingipain R], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.37 3.4.22.37] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ief FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ief OCA], [https://pdbe.org/4ief PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ief RCSB], [https://www.ebi.ac.uk/pdbsum/4ief PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ief ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ief FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ief OCA], [http://pdbe.org/4ief PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ief RCSB], [http://www.ebi.ac.uk/pdbsum/4ief PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ief ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CPG2_PORGI CPG2_PORGI]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Its proteolytic activity is a major factor in both periodontal tissue destruction and in bacterial host defense mechanisms. Activates complement C3 and C5 (By similarity).
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[https://www.uniprot.org/uniprot/CPG2_PORGI CPG2_PORGI] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Its proteolytic activity is a major factor in both periodontal tissue destruction and in bacterial host defense mechanisms. Activates complement C3 and C5 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gingipain R]]
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[[Category: Large Structures]]
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[[Category: Diego, I de]]
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[[Category: Porphyromonas gingivalis W83]]
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[[Category: Gomis-Ruth, F X]]
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[[Category: Gomis-Ruth FX]]
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[[Category: Guevara, T]]
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[[Category: Guevara T]]
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[[Category: Potempa, B]]
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[[Category: Potempa B]]
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[[Category: Potempa, J]]
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[[Category: Potempa J]]
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[[Category: Sztukowska, M]]
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[[Category: Sztukowska M]]
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[[Category: Veillard, F T]]
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[[Category: Veillard FT]]
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[[Category: Alpha/beta/alpha sandwich]]
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[[Category: De Diego I]]
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[[Category: Cysteine endopeptidase]]
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[[Category: Hydrolase]]
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Current revision

Complex of Porphyromonas gingivalis RgpB pro- and mature domains

PDB ID 4ief

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