This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jr7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:11, 20 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
==Solution structure of human DESR1==
==Solution structure of human DESR1==
-
<StructureSection load='2jr7' size='340' side='right' caption='[[2jr7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2jr7' size='340' side='right'caption='[[2jr7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2jr7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JR7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2jr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JR7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr7 OCA], [http://pdbe.org/2jr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2jr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jr7 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr7 OCA], [https://pdbe.org/2jr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jr7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/DPH3_HUMAN DPH3_HUMAN]] Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity).<ref>PMID:14980502</ref> <ref>PMID:14527407</ref> Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.<ref>PMID:14980502</ref> <ref>PMID:14527407</ref>
+
[https://www.uniprot.org/uniprot/DPH3_HUMAN DPH3_HUMAN] Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity).<ref>PMID:14980502</ref> <ref>PMID:14527407</ref> Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.<ref>PMID:14980502</ref> <ref>PMID:14527407</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jr7_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jr7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 23: Line 24:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Shi, Y]]
+
[[Category: Homo sapiens]]
-
[[Category: Wu, F]]
+
[[Category: Large Structures]]
-
[[Category: Wu, J]]
+
[[Category: Shi Y]]
-
[[Category: Csl zinc finger]]
+
[[Category: Wu F]]
-
[[Category: Desr1]]
+
[[Category: Wu J]]
-
[[Category: Metal binding protein]]
+

Current revision

Solution structure of human DESR1

PDB ID 2jr7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jr7"
Personal tools